Recent Publications

Peroxisomal β-oxidation—A metabolic pathway with multiple functions. Yves Poirier, Vasily D. Antonenkov, Tuomo Glumoff & J. Kalervo Hiltunen. Biochim. Biophys. Acta - Mol. Cell Res. 1763 (2006), 1413-1426.

Crystal structure of yeast peroxisomal multifunctional enzyme: structural basis for substrate specificity of (3R)-hydroxyacyl-CoA dehydrogenase units. Mari S. Ylianttila, Niko Pursiainen, Antti M. Haapalainen, André Juffer, Yves Pourier, J. Kalervo Hiltunen & Tuomo Glumoff. J. Mol. Biol. 358 (2006), 1286-1295.

Mutational spectrum of D-Bifunctional protein deficiency and structure-based genotype-phenotype analysis. S. Ferdinandusse, M.S. Ylianttila, J. Gloerich, M.K. Koski, W. Oostheim, H.R. Waterham, J.K. Hiltunen, R.J.A. Wanders & T. Glumoff. Am. J. Hum. Genet. 78 (2006), 112-124.

Structural biology of the thioester dependent degradation and synthesis of fatty acids. Prasenjit Bhaumik, M. Kristian Koski, Tuomo Glumoff, J. Kalervo Hiltunen & Rik K. Wierenga. Curr. Opin. Struct. Biol. 15 (2005), 621-628.

The crystal structure of 2-enoyl-CoA hydratase 2 domain of human peroxisomal multifunctional enzyme type 2. M. Kristian Koski, Antti M. Haapalainen, J. Kalervo Hiltunen & Tuomo Glumoff. J. Mol. Biol. 345 (2005), 1157-1169.

A two-domain structure of one subunit explains unique features of eukaryotic hydratase 2. M. Kristian Koski, Antti M. Haapalainen, J. Kalervo Hiltunen & Tuomo Glumoff. J. Biol. Chem. 279 (2004), 24666-24672.

Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 Å resolution. A.M. Haapalainen, M.K. Koski, Y-M. Qin, J.K. Hiltunen & T. Glumoff. Structure 11 (2003), 87-97.

Response of SCP-2L domain of human MFE-2 to ligand removal: Binding site closure and burial of peroxisomal targeting signal. M.F. Lensink, A.M. Haapalainen, J.K. Hiltunen, T. Glumoff & André H. Juffer. J. Mol. Biol. 323 (2002), 99-113.

Crystal structure of the liganded SCP-2 like domain of human peroxisomal multifunctional enzyme type 2 at 1.75 Å resolution. Antti M. Haapalainen, Daan M. F. van Aalten, Gitte Meriläinen, Jorma E. Jalonen, Päivi Pirilä, Rik K. Wierenga, J. Kalervo Hiltunen & Tuomo Glumoff. J. Mol. Biol. 313 (2001), 1127-1138.

Menetelmä polyhydroksialkanoaattisynteesissä prekursorimolekyyleinä toimivien (3R)-hydroksiasyyli-CoA-esterien kontrolloimiseksi geneettisesti modifioiduissa organismeissa. Kalervo Hiltunen & Tuomo Glumoff, 2003. Suomalainen patentti no. 111087.